Many of us are mindful of the truth that slimming is a mega-dollar industry. With millions, or even vast amounts of people of all ages struggling to lose weight, and also few pharmaceutically effective medications offered to assist them, the desperate public will literally clutch at straws.
Each week sees the launch of a new “miracle” diet pill or potion and a “surefire” diet sure to help believers shed kilos like magic.
Recently dr oz and garcinia cambogia dosage had become the flavour of the year. When you search the net for facts about this exotic fruit extract you will be assured that it is finally the miracle many of us have been waiting for, which will produce dramatic weight reduction. Endorsements by various TV personalities and other luminaries have included with the allure of Garcinia cambogia slimming products.
Based on a recent local study from your Tshwane University of Technology (TUT) “this small fruit, similar to a pumpkin in looks, is presently most popularly used and widely advertised like a weight-loss supplement”.
The comprehensive overview from TUT implies that studies have shown that “the extracts as well as (-)-hydroxycitric acid (HCA), a primary organic acid aspect of the fruit rind, exhibited anti-obesity activity”. In addition, it regulates the serotonin levels related to satiety, leading to reduced food consumption.
“According to clinical trial reports, Garcinia extracts were useful to obese individuals oftentimes. In addition, studies about the toxicity and observations during clinical trials indicate that Garcinia is safe to use. Many of the negative reports are already relevant to cases where multi ingredient formulations were consumed along with the effect could not attributed to a unique ingredient.”
The investigation does, however, caution against an increase in serotonin, especially in those who take medicines which are already increasing serotonin levels, for example SSRIs. Research into these effects has not been conducted.
“Moreover, regulatory authorities must provide and enforce legislation requiring the compulsory basic safety demonstration of supplements pre-marketing and develop post-marketing surveillance systems,” the investigation concluded.
Dr Ingrid van Heerden, an authorized dietitian, is of opinion that we should be cautious of does garcinia cambogia really work for weight loss, since it has not yet undergone rigorous testing. What follows is reviewed information from her pen, including her final verdict:
Often, once an individual who wants, or needs to lose excess weight, is hooked on the promise of a slim, sexy figure, these are sucked in to the deception. In the event the drops, wafers or powders don’t work, well then its the fault of the user who failed to abide by one or other often impossible instruction for example “stick to a 500 kcal/day diet” or “drink 5 litres of water a day”, never that relating to the diet plan pill.
When eventually science and legislation catch up with the manufacturers, they calmly take product A away from the market, change their formulation slightly, change the name to product B, and after that blithely sell product B using the same advertising gambits as before, raking in the money and pulling the wool over everyone’s eyes yet again.
Consistent with the ever-changing slimming product ranges, there are what one can call “ingredients of the year” (sometimes an ingredient lasts for only three to six months, however some have longer life spans, and then obviously some are resurrected every two or three years).
We certainly have had apple cider vinegar (which contains made many a comeback through the years), green tea leaf (which has earned some merit in scientific studies), hoodia (which just will not find a way to make the research results that will make it a front-runner), willow bark (or salicylic acid which is perfect for aches and pains yet not as efficacious for slimming), and traditional caffeine (that has a diuretic effect thus assisting you to lose fat until you replenish the liquid in your body, plus a stimulant effect when taken in big amounts that can be potentially dangerous), to name but a number of.
Even though it is perfectly possible that more extensive and well controlled scientific studies will disclose an extract of Garcinia cambogia containing a chemical called hydroxycitric acid (HCA) will help weight reduction, we have been at present not even sure how this tamarind or brindall berry or brindleberry or Garcinia gummi-gutta works, what side-effects it may or may not have and what dosage is needed to achieve really significant fat loss.
However I hear you say: “For once there exists a quantity of scientific tests that have been conducted with Garcinia cambogia, so what’s the issue?”
Well a few of the studies failed to show any weight reduction differences between patients who took Garcinia pills and those who took dummy pills, while other studies did show differences in weight reduction with the subjects taking pills containing Garcinia losing slightly more weight compared to those that failed to (Marquez et al, 2012).
A number of these weight-loss differences were not exactly exciting either, therefore we can’t say for certain that Garcinia cambogia does promote weight loss. Furthermore, it seems likely that this may not be the wonder pill it really is made over to be.
Additionally, a lot of the studies conducted up to now have been flawed (Critchley, 2013) . What this means is for example that in a single study the control and experimental subjects were not well matched (i.e. they did not have a similar starting weight, age, portion of excess fat etc.), whilst in other studies too few subjects were utilized to the leads to be significant.
For your results of studies being plausible one must compare “apples with apples” (i.e. well-matched subjects and controls) and also you need not only a number of subjects to produce a similar result.
On the positive side, we are able to point out that there may be some evidence that Garcinia cambogia products may aid weight loss during a period of 12 weeks. No reports have been conducted for prolonged periods as yet (Marquez et al, 2012), that is also viewed as a drawback.
Additionally there is at the moment a disagreement about the safety of pills containing Garcinia cambogia – one selection of researchers slates the pills as dangerous and hepatotoxic (causing liver damage) (Kim et al, 2013), while another group refutes this (Clouatre & Preuss, 2013). Marquez and his awesome coworkers (2012) claim that “at the doses usually administered, no differences have been reported regarding adverse reactions or adverse events (those studied) in humans between individuals treated with G. cambogia and controls.”
Ano Lob (2009), a public health consultant in the usa has published a warning regarding the hepatotoxicity of a fat loss product called “Hydroxycut”, which contains Garcinia cambogia. This writer collected case reports of patients who developed liver toxicity associated with the aforementioned weight loss product.
Evidently approximately one million units on this hydroxycitric acid product are offered a year in the us. The patients who developed hepatotoxicity reported indications of fatigue, nausea, vomiting, cramps, fever, chills, abdominal pain, and jaundice.
While the amount of hepatotoxicity cases reported were only a few, Lob points out that monitoring of adverse events connected with vitamin supplements such as these weight loss products is woefully inadequate in the usa (as is the case in several other countries, including South Africa), together with the FDA only receiving about 1% of such negative reports.
According to Lob (2009), the Poison Control Centres in the us are more inclined to receive reports of adverse events associated with health supplements but are not equipped to coordinate such findings.
He cites the truly sobering illustration of something called “Metabolife 356″ that was sold as a weight loss supplement in America. Lob’s states that the manufacturers received 14 000 reports over a period of five years that documented “serious adverse events associated with their ephedra-containing product” which dexrpky17 cardiac arrest, strokes, convulsions and fatalities.
The manufacturers failed to inform the FDA or some other US government authority of those reports. As astounding because this might sound, manufacturers of dietary supplements usually are not expected to meet some of the specifications that happen to be strictly enforced in relation to food and pharmaceutical products (medicines), so they can take advantage of this “ethical loophole” never to publish reports of negative and harmful events.
Eventually these events arrived at light and ephedra-containing products for slimming and also other uses were banned in the USA.
The implication contain in Lob’s warning is the fact that HCA or Garcinia cambogia extract can also be potentially toxic unless sufficient, reliable evidence towards the contrary is manufactured available.
In the present moment, we have no idea enough about slimming goods that contain pure garcinia cambogia side effects to freely recommend its use. I often go along with Astell and coworkers (2013) who conducted a systematic review of double blind randomised controlled clinical studies to gauge evidence seen on the efficacy of current health supplements used to control appetite and/or weight.
These authors concluded that “According to the finding out of this systematic review, the evidence is just not convincing in demonstrating that a lot of nutritional supplements used as appetite suppressants for weight-loss in dealing with obesity are effective and safe.”
Basically we wait for more extensive and conclusive evidence obtained with larger numbers of well-matched test subjects treated for much longer periods with all the “gold standard” of double blind randomised controlled clinical studies, rather avoid using any weight-loss supplement that has not been tested thoroughly.